Helicobacter pylori and Hyperemesis Gravidarum Continuous Study (2)

Purpose: To evaluate the role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum, and the value of adding a non teratogenic regimen for its treatment in intractable cases. Methods: Sixty two hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A full history was taken including history of medical disorders as peptic ulcer and history of chronic medications intake as non steroidal anti-inflammatory drugs. General and local examination was done for all cases. Ultrasound was done to exclude obstetric causes of hyperemesis as twin pregnancy, molar pregnancy or missed abortion. Sixty two normal pregnant women were used as control. Serum test for H-pylori IgG antibody titre using (ELISA) method was done for all patients and control. Statistical analysis of the data was done. Results: Fifty four cases of the Sixty two HG cases were H pylori positive and twenty out of the Sixty two control were positive , six cases developed severe intractable vomiting. Two of them developed an attack of hematemesis. Gastroscopy in these case revealed severe antral gastritis , duodenitits,(and gastric and duodenal erosions in two of them). The six patients received non teratogenic regimen for treatment. Attacks of vomiting decreased and pregnancy continued till delivery of healthy newborns. Conclusion: Screening for Helicobacter pylori should be added to the investigations of HG cases. Non teratogenic treatment can be considered in intractable cases. [Researcher. 2010;2(5):76-80]. (ISSN: 1553-9865).